BioTeZ offers a wide range of products and services in the field of Human Proteases Research, such as human MMPs (Matrix Metalloproteinases), human ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin motifs) or human HtrAs (High temperature requirement factor A) to support drug development, especially therapeutic or neutralizing antibodies, antibody drug conjugates (ADC) or target screening and diagnostics, e.g. for preclinical phases, trials, pharmacokinetic (pk) and pharmacodynamic (pd) studies.
Proteases have relevance in the control of multiple biological processes in all living organisms. They regulate the activities of many proteins, modulate protein-protein interactions, create new bioactive molecules, contribute to the processing of cellular information and generate, transduce and amplify molecular signals. As a direct result of these multiple actions, proteases influence DNA replication and transcription, cell proliferation and differentiation, tissue morphogenesis and remodelling, heat shock and unfolded protein responses, angiogenesis, neurogenesis, ovulation, fertilization, wound repair, stem cell mobilization, haemostasis, blood coagulation, inflammation, immunity, autophagy, senescence, necrosis and apoptosis. Consistent with these essential roles of proteases in cell behaviour, survival and death of all organisms, alterations in proteolytic systems underlie multiple pathological conditions such as cancer, neurodegenerative disorders, inflammatory and cardiovascular diseases.
Our high quality proteins are produced in bacteria and insect cells (Baculovirus expression system) or are isolated from biological fluids.

Test kits, components and services for sensitive determination of protease concentration and protease activity fall within the scope of our Human Proteases Research. We combine the best elements of bead and ELISA technologies. This guarantees high sensitivity and specificity for many applications in various volumes and overcomes the problems caused by the interference of other proteins with the same molecular weight or the inhibition of specific protease detection due to the presence of an abundant amount of other proteins.


 human protease research at BioTeZ

 

human protease ELISA             Human protease antibodies           human protease references


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The Human Proteases Research Platform was granted by IBB (Investionsbank Berlin) and ZIM (Zentrales Innovationsprogramm Mittelstand).
Various research projects in the field of human proteases immuno assay development were co-financed by European Union  - EFRE

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BioTeZ GmbH

Die BioTeZ Berlin-Buch GmbH ist ein Biotechnologie-Unternehmen und wurde 1992 gegründet. BioTeZ ist Partner der Forschung, der Pharmaindustrie und der Labordiagnostik.

  • Biodiagnostika
  • Oligonukleotide
  • Markierte Biomoleküle

Kontakt

BioTeZ Berlin Buch GmbH
Robert-Rössle-Strasse 10, Haus D 72
13125 Berlin - Germany

Tel: +49 30-9489-2130
Fax: +49 30-9494-509
E-Mail: info@biotez.de
www.biotez.de

Events

Meet BioTeZ at MEDICA, 13-16 Nov. 2017, Düsseldorf. Get Information about diagnostics and biotechnological services we offer: Therapeutic Drug Monitoring, Mycotoxin and Vitamin Analysis, Oligonucleotides, Human Proteases Research, Streptavidin Coatings


Biologics and Biosimilars Congress 2017 BerlinBioTeZ will present the latest research results from collaboration projects at the 3rd Biologics and Biosimilars Congress (6-7 March 2017); Summarizing outcomes of therapeutic drug monitoring studies with Omalizumab/IgE, Adalimumab/TNF and provide insights into Alirocumab, Evolocumab/PCSK9 recoveryELISA projects